James N Sleigh Selected Research

Type 2D Charcot-Marie-Tooth disease

1/2020	Altered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels.
1/2020	Developmental demands contribute to early neuromuscular degeneration in CMT2D mice.
1/2018	Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Drosophila Model of Peripheral Neuropathy.
1/2017	Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis.
3/2016	Synaptic Deficits at Neuromuscular Junctions in Two Mouse Models of Charcot-Marie-Tooth Type 2d.
5/2014	Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice.

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James N Sleigh Research Topics

Disease

8	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 10/2018 - 10/2010
6	Type 2D Charcot-Marie-Tooth disease 01/2020 - 05/2014
2	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/2022 - 05/2013
2	Neuromuscular Diseases (Neuromuscular Disease) 10/2021 - 01/2016
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2019 - 04/2014
1	Frontotemporal Dementia (Semantic Dementia) 11/2019
1	Neuroinflammatory Diseases 11/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2019
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2018
1	Muscle Cramp (Cramp) 03/2016
1	Hypoxia (Hypoxemia) 02/2016
1	Nerve Degeneration 05/2014

Drug/Important Bio-Agent (IBA)

4	Proteins (Proteins, Gene)FDA Link 01/2018 - 10/2010
3	EnzymesIBA 10/2018 - 05/2014
3	Glycine-tRNA LigaseIBA 01/2018 - 05/2014
2	Pharmaceutical PreparationsIBA 01/2022 - 01/2011
1	Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA 01/2020
1	DNA-Binding Proteins (DNA Binding Protein)IBA 11/2019
1	UbiquitinIBA 10/2018
1	Semaphorins (Semaphorin)IBA 01/2018
1	plexinIBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017
1	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 03/2016
1	pimonidazoleIBA 02/2016
1	Antisense OligonucleotidesIBA 01/2016
1	OligonucleotidesIBA 01/2016
1	Peptides (Polypeptides)IBA 01/2016
1	Superoxide Dismutase-1IBA 04/2014
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 05/2013

Therapy/Procedure

3	Denervation 10/2021 - 03/2016
3	Therapeutics 01/2016 - 12/2011
1	Muscle Denervation 11/2019